scglue.genomics.build_tf_target_network

scglue.genomics.build_tf_target_network(rna, atac, gene2peak, genes, peaks, tfs, motif_bed)

Build TF-target regulatory network using SCENIC approach

Parameters:

• rna (AnnData) – RNA AnnData

• atac (AnnData) – ATAC AnnData

• gene2peak (Graph) – Gene to peak graph

• genes (typing.List[str]) – List of genes

• peaks (typing.List[str]) – List of peaks

• tfs (typing.List[str]) – List of transcription factors

• motif_bed (scglue.genomics.Bed) – Motif BED

Return type:

Graph

Returns:

grn – TF-target regulatory network